[3LBA-056] Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations

○Hiroki Kobayashi^1,2, Hideyuki Hatakeyama³, Haruna Nishimura¹, Mutsumi Yokota³, Sadafumi Suzuki³, Yuri Tomabechi⁴, Mikako Shirouzu⁴, Hiroyuki Osada⁵, Masakazu Mimaki⁶, Yu-ichi Goto^3,7, Minoru Yoshida^1,8,9 (1.Drug Disc. Seed Comp. Explor. Unit, 2.Lab. of Oncol., Dept. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 3.Dept. of Mental Retardation and Birth Defect Res., NCNP, 4.Lab. for Protein Functional and Struct. Biol., RIKEN BDR , 5.Chem. Biol. Res. Gr., RIKEN CSRS, 6.Dept. of Pediatrics, Teikyo Univ. Sch. of Med., 7.Med. Genome Center, NCNP, 8.Chem. Genomics Res. Gr., RIKEN CSRS, 9.Dept. of Biotechnol. & CRIIM, Univ. of Tokyo)

glycolysis, MELAS, mitochondrial disease, PFK1 (phosphofructokinase-1), Warburg effect