[3P-0258] Pharmacological activation of SERCA ameliorates dystrophic phenotypes and mitochondrial respiratory function in dystrophin-deficient mdx mice

○KENICHIRO NOGAMI^1,2, Yusuke Maruyama^1,3, Fusako Takemura¹, Norio Motohashi¹, Ahmed Elhussieny⁴, Michihiro Imamura¹, Satoshi Miyashita⁵, Megumu Ogawa⁶, Satoru Noguchi^6,7, Katsuya Miyake⁹, Yuki Tamura¹⁰, Jun-ichi Kira², Yoshitsugu Aoki¹, Shin'ichi Takeda⁸, Yuko Suzuki¹ (1.Dept. of Mol. Ther., Natl. Inst. of Neurosci., NCNP, 2.Dept. of Neurol., Grad. Sch. of Med. sci., Kyushu Univ., 3.Dept. of gen. reg., Grad. Sch. of Pharm. Sci., Tokyo Univ. of Sci., 4.Dept. of Neurol., Fac. of Med., Minia Univ., 5.Dept. of Biochem. and Cell. Biol., Natl. Inst. of Neurosci., NCNP, 6.Dept. of Neuromuscul. Res., Natl. Inst. of Neurosci., NCNP, 7.Dept. of Clin. Dev., Transl. Med. Ctr., NCNP, 8.NCNP, 9.Ctr. for Basic Med. Res., Int'l. Univ. of Health and Welfare , 10.Res. Inst. for Sport Sci., Nippon Sport Sci. Univ.)

Duchenne muscular dystrophy, skeletal muscle, calcium, Sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), mitochondria