Development of &#34;TCR cassette method&#34: CTLs are regenerated from iPSCs in which tumor-antigen specific TCR genes can be efficiently introduced into the endogenous TCR locus by cassette exchange.

○Koji Terada, Kenta Kondo, Seiji Nagano, Kyoko Masuda, Hiroshi Kawamoto, Yasutoshi Agata

[3P-0301] Development of "TCR cassette method": CTLs are regenerated from iPSCs in which tumor-antigen specific TCR genes can be efficiently introduced into the endogenous TCR locus by cassette exchange.

○Koji Terada¹, Kenta Kondo¹, Seiji Nagano², Kyoko Masuda², Hiroshi Kawamoto², Yasutoshi Agata¹ (1.Dept. of Mol. Phys. Chem., Shiga Univ. of Med. Sci., 2.Lab. of Immunol., Inst. for Front. Life and Med. Sci., Kyoto Univ.)

TCR, CTL, iPS, cancer immunotherapy, genome editing

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The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0301] Development of "TCR cassette method": CTLs are regenerated from iPSCs in which tumor-antigen specific TCR genes can be efficiently introduced into the endogenous TCR locus by cassette exchange.

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