Can increasing the antigen-binding valency lead to enhance the cytotoxicity of bispecific T cell-recruiting antibodies against cancer cells?

○Airi Suzuki, Yusuke Ikeuchi, Masaya Kitamura, Takeshi Nakanishi

[3P-0376] Can increasing the antigen-binding valency lead to enhance the cytotoxicity of bispecific T cell-recruiting antibodies against cancer cells?

○Airi Suzuki¹, Yusuke Ikeuchi¹, Masaya Kitamura¹, Takeshi Nakanishi¹ (1.Dept. of Appl. Chem. and Bioeng., Grad. Sch. of Eng., Osaka City Univ.)

Antigen-binding valency, Antibody engineering, Bispecific antibody, Cancer immunotherapy, T cell recruitment

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The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0376] Can increasing the antigen-binding valency lead to enhance the cytotoxicity of bispecific T cell-recruiting antibodies against cancer cells?

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