[1P-077] Application of chromosome engineering technology (5): Construction of top-down HAC derived from chromosome 21 in human iPS cells by megabase deletion using genome editing (CRISPR/Cas9)

^○Masaya Egawa¹, Narumi Uno¹, Hitomaru Miyamoto², Yusuke Ohkame³, Rina Komazaki¹, Yuki Ishizu¹, Yusaku Okano¹, Taku Yunomae¹, Yasuhiro Kazuki^2,3,4, Kazuma Tomizuka¹ (1.Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm and Life Sci, 2.Div. of Chromo. Biomed Eng., Grad. Sch. of Med. Sci., Tottori Univ., 3.CERC, Tottori Univ., 4.Chr. Eng. Group, ExCELLS)