[1P-713] Tyrosine hydroxylase in dopaminergic neuron translationally modifies α-synuclein tyrosine residue, promoting the oligomeric aggregation.

^○Sakiko Matsumoto¹, Mingyue Jin¹, Takashi Ayaki², Hodaka Yamakado², Ayumu Konno³, Hirokazu Hirai³, Toshifumi Takao⁴, Shinji Hirotsune¹ (1.Dept. of Genetic Dis. Res., Grad. Sch. of Med., Osaka Metropolitan Univ., 2.Dept. of Neurol., Grad. Sch. of Med., Kyoto Univ., 3.Dept. of Neurophysiol & Neural Repair, Grad. Sch. of Med., Gunma Univ., 4.Lab. of Prot. Profiling & Functional Proteomics, Osaka Univ. Inst. for Prot. Res.)