[2P-195] The 2’-formamide modification in the siRNA seed region reduces off-target effects by two different mechanisms

^○Seongjin An¹, Yoshiaki Kobayashi², Kohei Nomura³, Yasuaki Kimura³, Hiroshi Abe³, Dai Akase⁴, Misako Aida⁵, Kumiko UiTei^1,2 (1.Graduate School of Frontier Sciences, The University of Tokyo, 2.Graduate School of Science, The University of Tokyo, 3.Graduate School of Science, Nagoya University, 4.Graduate School of Advanced Science and Engineering, Hiroshima University, 5.Office of Academic Research and Industry-Academia-Government and Community Collaboration, Hiroshima University)