9:50 AM - 10:15 AM

[3AW-06-3] IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia

^○Xiaoxiao Liu¹, Naru Sato², Tomohiro Yabushita², Moe Tamura², Shuhei Asada², Takeshi Fujino², Tsuyoshi Fukushima², Taishi Yonezawa², Yosuke Tanaka², Tomofusa Fukuyama², Akiho Tsuchiya², Shiori Shikata², Hiroyuki Iwamura³, Chieko Kinouchi⁴, Kensuke Komatsu⁴, Satoshi Yamasaki⁵, Tatsuhiro Shibata⁵, Atsuo Sasaki⁶, Yuki Sugiura⁷, Hitoshi Takizawa⁸, Takuma Shibata⁹, Kensuke Miyake⁹, Toshio Kitamura², Susumu Goyama² (1.Dvi. of Mol. Oncol., Dept. of CBMS, Grad. Sch. of Frontier Sci., Univ. of Tokyo, 2.Div. of Cell. Therapy, IMSUT, 3.FUJIFILM Corp. Pharm. PD. Div., 4.FUJIFILM Corp. Pharm.&Healthcare Res. Lab, 5.Lab of Mol. Med., Human Genome Center, IMSUT, 6.Div. of Hem. and Onocol., Dept. of Internal Med., Univ. of Cincinnati, 7.Sch. of Med. Dept.t of Biochemistry, Keio Uni., 8.Lab. of Stem Cell Stress, IRCMS, Kumamoto Uni., 9.Div. of Infectious Genetics, Dept. of Microbiology & Immunology, IMSUT)