[2P-186_2SP-02-05] The promising chemical modifications in the siRNA seed region that can avoid off-target effects by steric hindrance or thermodynamic stability

^○Seongjin An¹, Yoshiaki Kobayashi², Kohei Nomura³, Yasuaki Kimura³, Hiroshi Abe³, Akase Dai⁴, Misako Aida⁵, Kumiko UiTei^1,2 (1.Grad. Sch. of Frontier Sci., Univ. of Tokyo, 2.Grad. Sch. of Sci., Univ. of Tokyo, 3.Grad. Sch. of Sci., Nagoya Univ, 4.AIDI Center, Hiroshima Univ, 5.ORACC, Hiroshima Univ.)