[2P-843] Clonal evolution of ERK MAPK signal heterogeneity revealed by live imaging of human pancreatic cancer organoids

^○TORU HIRATSUKA¹, Shoko Tsukamoto², Al Koussa Houssam², Ai Takatsu¹, Akihito Machinaga³, Nobuyuki Kakiuchi^4,5, Seishi Ogawa^6,5,4, Hiroshi Seno⁷, Shigeki Higashiyama¹, Michiyuki Matsuda^8,2 (1.Dept. of Oncogenesis and Growth Regulation, Osaka International Cancer Inst., 2.Lab. of Bioimaging and Cell Signaling, Kyoto Univ., 3.Discovery, Med. Creation, OBG, Eisai Co., Ltd,, 4.Dept. of Pathol. and Tumor Biol., Kyoto Univ., 5.WPI-ASHBi, Kyoto Univ., 6.Dept. Med., Karolinska Inst., Stockholm, Sweden, 7.Dept. of Gastroenterol and Hepatol., Kyoto Univ., 8.Dept. of Path. and Biol. of Diseases, Kyoto Univ.)