In this study, highly-sensitive piezoresistive strain sen-sors based on gold nanoparticle thin films deposited on a stretchable PDMS substrate by centrifugation were de-veloped to measure arterial pulse waveform. The gauge factors of nanoparticle thin film sensors can be opti-mized up to 419 in tensile mode and 260 in compressive mode. It has been demonstrated that nanoparticle thin film sensors on PDMS substrates were successfully ap-plied to sense arterial pulses at human body.