The Japan Society of Applied Physics

2023 International Conference on Solid State Devices and Materials

2023 International Conference on Solid State Devices and Materials

Sep 5, 2023 - Oct 31, 2023
Nagoya Congress Center

9:00 AM - 9:15 AM

[D-5-01] Desmoplasia in Endothelial Cells and Anti-Cancer Drug Resistance: One Chip Microengineered Tumor Model

○Madhushree Poddar1, Yu-de Chu2, Chau-Ting Yeh2, Cheng-Hsien Liu1 (1. National Tsing Hua University (Taiwan), 2. Chang Gung Memorial Hospital (Taiwan))

https://doi.org/10.7567/SSDM.2023.D-5-01

For regenerative medicine, the need for three-dimensional (3D) tissue models reproducing liver structures and functions is growing. In this work, we provide a single, exceptional polydimethylsiloxane (PDMS) microfluidic chip to demonstrate how endothelial cells can change their phenotype to take on a mesenchymal profile. With reliable culture, we hope to pave the way for a variety of biological uses, such as drug detection. This chip has three cell-culture chambers that demonstrate anti-cancer drug resistance when liver cancer cells and endothelial cells are cultured together in a gelatin methacryloyl (GelMA) hydrogel-based matrix.