[B104-1vn] 16. Natural Products Chemistry, Chemical Biology

[B104-1vn-03] Development of an introduction of a tertiary hydroxyl group at C11 in the saxitoxin (STX) skeleton and application to the synthesis of a new STX derivative

^○Ayato Nureki¹, Yuka Takayanagi¹, Minami Hoshi¹, Hayete Ishizuka¹, Osamu Chiba², Takatsugu Hirokawa^3,4, Keiichi Konoki², Mari Yamashita², Kazuo Nagasawa¹ (1. Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2. Graduate School of Agricultural science, Tohoku University, 3. Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, 4. Division of Biomedical Science, University of Tsukuba)

[Lang.] Japanese

Keywords:saxitoxin, guanidine alkaloid, voltage-gated sodium channel, structure-activity relationship