[G201-3pm] 17. Biofunctional Chemistry, Biotechnology

[G201-3pm-04] FixEL: a new method for visualizing ligand dynamics in the brain by reframing the PFA fixation chemistry.

^○Takeharu Mino¹, Hiroshi Nonaka^1,2, Seiji Sakamoto¹, Jae Hoon Oh², Yu Watanabe¹, Mamoru Ishikawa², Akihiro Tsushima¹, Kazuma Amaike¹, Shigeki Kiyonaka^2,3, Tomonori Tamura^1,2, Radu Aricescu^4,5, Wataru Kakegawa^2,6, Eriko Miura⁶, Michisuke Yuzaki⁶, Itaru Hamachi^1,2 (1. Graduate School of Engineering, Kyoto University, 2. JST ERATO, 3. Graduate School of Engineering, Nagoya University, 4. Division of Structural Biology, University of Oxford, 5. Neurobiology Division, MRC Laboratory of Molecular Biology, 6. Keio University School of Medicine)

[Lang.] English

Keywords:Ligand-protein interaction, Endogenous glutamate receptor, Endogenous GABA receptor, Nanobody, 3D imaging