[1P] F. Disorders of the Nervous System 2

[1P-259] In vivo wide-field Ca²⁺ imaging of the cortical spontaneous activity in the Cdkl5 kinase-dead knock-in mice reveals altered functional connectivity in large-scale cortical networks upon the loss-of-function of CDKL5

*Toshiki Nomura¹, Tomonari Murakami², Kumiko Saitou^2,4, Kenichi Ohki^2,3, Teruyuki Tanaka¹ (1. Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, 2. Department of Physiology, Graduate School of Medicine, The University of Tokyo, 3. International Research Center for Neurointelligence (IRCN), The University of Tokyo, 4. Neural Circuit Unit, Okinawa Institute of Science and Technology Graduate University (OIST))

Keywords:CDKL5, In vivo wide-field Ca2+ imaging, kinase-dead KI mouse, functional connectivity