[18p-C206-1~8] 1.1 応用物理一般・学際領域

[18p-C206-3] Effect of Spin Degree of Freedom on the Reaction of O₂ with Hemoglobin

Daiichi Kurokawa¹、Jessiel Siaron Gueriba^1,2、〇Wilson Agerico Tan Dino^1,3 (1.AP Osaka Univ.、2.Phys. DLSU、3.CAMT Osaka Univ.)

キーワード：oxygen, spin degree of freedom, hemoglobin

Here, we report results of our study on the mechanism of spin-dependent O₂ reaction with hemoglobin. O₂ reaction with hemoglobin, which we represent as FePIm (Fe = iron, P = porphyrin, Im = imidazole), involves the transition between two spin-dependent states, viz., the oxyhemoglobin state and the deoxyhemoglobin state. The deoxyhemoglobin state pertains to FePIm and a free O₂, while the oxyhemoglobin state pertains to an O₂ bound to FePIm. The deoxyhemoglobin and oxyhemoglobin systems have triplet and singlet total magnetizations, respectively. We found that a spin transition from triplet to quintet to singlet mediates the O₂ binding process, and this accelerates the reaction. We also found that the position of the Fe atom out of the porphyrin plane is an important indicator of O₂ affinity. These results indicate that spin transitions/crossings affect the activation energy barrier. Further details will be discussed at the meeting.