[S-16] Insights into the disease concept and the boarder of NMOSD and MS

[S-16-3] 日本におけるMS研究の臨床および疫学的観点から

宮本 勝一 (近畿大学病院 神経内科)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

Education:
Year Degree Institute
1992 M.D. Faculty of Medicine, Kindai University, Osaka, Japan
2000 Ph.D. Graduate School of Medicine, Kyoto University, Kyoto, Japan

Postdoctoral Traning:
Year Specialty Institute
1992-94 Internal medicine Osaka Red Cross Hospital, Osaka, Japan
1994-96 Neurology Osaka Red Cross Hospital, Osaka, Japan

Academic Appointment:
Year Position title Institute
2000-02 Research fellow National Institute of Neuroscience, NCNP, Tokyo, Japan
2002-04 Research fellow Harvard Medical School, Boston, USA
2004-11 Assistant Professor Faculty of Medicine, Kindai University, Osaka, Japan
2011- Associate Professor Faculty of Medicine, Kindai University, Osaka, Japan