Symposium

[S25] Challenges to breakthrough in the drug discovery and development by young pharmacological researchers

Sun. Mar 27, 2022 9:30 AM - 11:30 AM [Room R] Shirotori Hall (South) (Bldg. 4: 1F)

Organizer: Hideaki Tagashira (Dept. Pharmacol., Fac. Med., Fukuoka Univ.), Kazuharu Furutani (Dept. Pharmacol., Fac. Pharmaceut. Sci., Tokushima Bunri Univ.)

The scientific breakthroughs are emerging scientific advances for innovating the research fields. In this symposium, six young and energetic researchers will introduce their cases of the ongoing challenges to break through the barriers that stand in the way of drug discovery and development. The topics include that 1) novel GPCR regulation mechanism and colitis (Nishiyama), 2) RNA phase separation driving the pathogenic prion-like protein aggregation in neurodegenerative diseases (Yabuki), 3) age-dependent decline in remyelination capacity as a novel target for encephalomyelitis (Muramatsu), 4) the excitation-transcription coupling underlying the disease-related vascular remodeling (Suzuki), 5) the important relationship between Mg²⁺ metabolisms and cardiovascular diseases (Tagashira), and 6) a new method to reduce skeletal muscle inflammation caused by infections (Sakamoto). We will discuss with the audience on the floor how to use the new idea and techniques to solve the problems in other research. We will also discuss how to develop them into drug discovery and development. We hope that this symposium will allow us to read trends in the changing research field and discover potential issues that will lead to the next breakthroughs.

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オーガナイザー挨拶：田頭秀章（福岡大医） (9:30 AM - 9:35 AM)

9:35 AM - 9:53 AM

[S25-1] Elucidation of internalization mechanism of GPCR through cysteine modification

○Kazuhiro Nishiyama¹, Akiyuki Nishimura^2,3, Yuri Kato¹, Kakeru Shimoda^2,3, Motohiro Nishida^1,2,3 (1. Grad. Sch. Pharm, Kyushu Univ., 2. Exploratory Research Center on Life and Living Systems (ExCELLS), NINS, 3. National Institute for Physiological Sciences (NIPS))

9:53 AM - 10:11 AM

[S25-2] RNA phase transition-induced aggregation of prion-like proteins in neurobiology and neuropharmacology.

○Yasushi Yabuki^1,2, Norifumi Shioda^1,2 (1. Dept. Genom Neuro. IMEG. Kumamoto Univ., 2. Grad. Sch. Pharm. Sci. Kumamoto Univ.)

10:11 AM - 10:29 AM

[S25-3] Age-dependent decline of remyelination capacity depends on circulating apelin

○Rieko Muramatsu¹ (1. NIN, NCNP)

10:29 AM - 10:47 AM

[S25-4] Excitation-transcription coupling causes vascular remodeling through a Cav1.2/CaMKK2/CaMK1a pathway

○Yoshiaki Suzuki¹, Yuji Imaizumi¹, Hisao Yamamura¹ (1. Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.)

10:47 AM - 11:05 AM

[S25-5] Cardiovascular research on abnormal Mg metabolism using TRPM7/CNNM2 genetically modified mice

○Hideaki Tagashira¹, Satomi Kita^1,2, Takahiro Iwamoto¹ (1. Dept. Pharmacol., Fac. Med., Fukuoka Univ., 2. Dept. Pharmacol., Fac. Pharmaceut. Sci., Tokushima Bunri Univ.)

11:05 AM - 11:23 AM

[S25-6] Preservation of skeletal muscle from septic insult

○Kazuho Sakamoto¹ (1. Sch. Pharm. Sci., Univ. Shizuoka)

総括：古谷和春（徳島文理大薬） (11:23 AM - 11:30 AM)

Session information