2017 Annual Meeting

Presentation information

Oral presentation

II. Radiation, Accelerator and Beam Technologies » 203-3 Application of Beams, Target

[1C06-10] Nano Structure Analysis by Micro-beam

Mon. Mar 27, 2017 2:45 PM - 4:05 PM Room C (16-203 Building No.16)

Chair: Noriyasu Hayashizaki (Tokyo Tech)

3:30 PM - 3:45 PM

[1C09] Fast heavy-ion radiation damage of biomolecules in aqueous solution using the vacuum liquid micro-jet technique

*Hidetsugu Tsuchida1, Shinji Nomura1, Akihiro Kajiwara1, Takuya Majima1, Manabu Saito1 (1. Kyoto University)

Keywords:Radiation damage of biomolecules, Radiolysis of aqueous solution, Heavy-ion irradiation

Fast heavy-ion radiolysis of biomolecules in aqueous solution is investigated for an atomistic understanding of radiation damage to normal cells during heavy-particle beam therapy. Two types of amino acids, glycine and proline, were used as model biomaterials. Microjets of aqueous solutions under vacuum were irradiated with 4.0-MeV carbon ions corresponding to energies in the Bragg peak region. To understand the effects of the water environment on molecular damage, the yield of molecular dissociation was measured by secondary ion mass spectroscopy. The yield was significantly reduced relative to gas-phase targets. This implies that the numerous water molecules surrounding a single biomolecule act as a buffer that suppresses dissociation.