[3O08-12] Accelertor and Componet Technology

[3O09] Study of domestic production of Ac-225 by electron linac

(2)Study of condition of linac-induced γ-ray irradiation to Ra-226 target by PHITS

*Akito Aichi¹, Masafumi Ozeki¹, Kunihiro Miyoshi¹, Mitsuru Uesaka¹ (1. Tokyo Univ.)

Keywords: Linear accelerator(LINAC), Targeted Alpha Therapy, Actinium-225, Radium-226, Radium target

Recently, radionuclide therapy using α-emitter has attracted attention as it can selectively attack local targeted areas. ²²⁵Ac, which has high cytotoxicity and optimal half-life, has been used as ²²⁵Ac-PSMA-617 for prostate cancer. However, to stably use ²²⁵Ac in the medical applications in Japan, its supply chain needs to be improved. For sufficient and domestic production of ²²⁵Ac, Uesaka laboratory in the University of Tokyo is designing an electron linac for γ-ray irradiation to a ²²⁶Ra target to invoke ²²⁵Ra decaying to ²²⁵Ac. We used PHITS to simulate the radiation interaction to optimize irradiation conditions. We will report an overall evaluation result about yield of ²²⁵Ra and other induced nuclides from the safety perspective.