[3H08-10] RI Production for Medicine

[3H09] Scale up experiment of Ac-225 production using an electron accelerator

(2)Separation, purification and quantitative evaluation of Ac-225

*Mizuho Maeda¹, Takahiro Tadokoro¹, Kento Nishida¹, Yuichiro Ueno¹, Takahiro Watanabe², Takahiro Sasaki², Masaharu Itoh², Hidetoshi Kikunaga³, Kenji Shirasaki⁴, Shun Sekimoto⁵ (1. Hitachi, Ltd., Research & Development Group, 2. Hitachi, Ltd., Smart Life Business Management Division, 3. ELPH, Tohoku Univ., 4. IMR, Tohoku Univ., 5. KURNS)

Keywords:Targeted Alpha Particle Therapy, Medical Radionuclides, Ra-226, Ac-225, Electron Linear Accelerator

Author: Yuko Kani¹, Shigeru Kashiwagi³, Tsutomu Ohtsuki⁵, Makoto Inagaki⁵

Ac-225 is a candidate nuclide for targeted alpha therapy (TAT). However, its radiopharmaceutical development has been prevented by insufficient supplies of Ac-225. We are developing a Ac-225 production method using an electron linear accelerator via Ra-226(γ, n)Ra-225 reaction, which has the advantages of producing no additional Ac isotopes. We performed a large-scale production experiment, using 50MBq of Ra-226 as a starting material. In this presentation, we report on the purification process and quantitative evaluation of Ac-225.