[1M14-15] Medical Applications of Radiation

[1M15] Scale up production of ²²⁵Ac using an electron linear accelerator and radiolabeling experiment

*Mizuho Maeda¹, Takahiro Tadokoro¹, Yuichiro Ueno¹, Takahiro Watanabe², Hidetoshi Kikunaga³, Kenji Shirasaki⁴, Mitsuyoshi Yoshimoto⁵, Hirofumi Fujii⁵, Shun Sekimoto⁶, Tsutomu Ohtsuki⁶ (1. Hitachi, R&D Group, 2. Hitachi, Helthcare Buisiness Division, 3. ELPH, Tohoku Univ., 4. IMR, Tohoku Univ., 5. NCC, Exploratory Oncology Research & Clinical Trial Center, 6. Institute for Integrated Radiation and Nuclear Science, Kyoto Univ. )

Keywords:Targeted Alpha Particle Therapy, Medical Radionuclides, Ra-226, Ac-225, Electron Linear Accelerator

Author: Yuko Kani¹, Kento Nishida¹, Takahiro Sasaki², Shigeru Kashiwagi³, Kazunobu Ohnuki⁵, Makoto Inagaki⁶, Satoshi Fukutani⁶, Yuji Shibahara^6
225Ac is recognized as one of the most suitable radionuclides for targeted alpha therapy (TAT). However, its current supply from ²²⁹Th natural decay is limited and establishment of another mass production route is desired. We have been devoloping an ²²⁵Ac production method using an electron linear accelerator in which no long-lived actinium isotopes are co-produced. We report the scale-up prodution of ²²⁵Ac and radiolabeling test using the produced radionuclide.