Childhood & Adolescent Disorders

[P490] The spatial cognitive dysfunction and microglial activation induced by adolescent social isolation through the hypoproduction of cystine by the damage of colonic goblet cells

*Moeka Tanabe^1,2, Kazuo Kunisawa¹, Imari Saito¹, Aika Kosuge¹, Hiroyuki Tezuka³, Tomoki Kawai¹, Masaya Hasegawa¹, Hisayoshi Kubota^1,4, Kuniaki Saito^2,5, Toshitaka Nabeshima^2,6, Akihiro Mouri^1,6 (1. Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Sciences, Aichi, Japan., 2. Laboratory of Health and Medical Science Innovation, Fujita Health University Graduate School of Health Science, Aichi, Japan., 3. Department of Cellular Function Analysis, Research Promotion Headquarters, Fujita Health University, Aichi, Japan., 4. Division of Behavioral Neuropharmacology, International Center for Brain Science (ICBS), Fujita Health University, Aichi, Japan., 5. Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Aichi, Japan., 6. Japanese Drug Organization of Appropriate Use and Research (J-DO), Aichi, Japan.)

Keywords:gut-brain axis, goblet cell, cystine, microglia