Preclinical - Others (2)

[P532] Sigma-1 receptor activation by fluvoxamine restores TFEB-mediated autophagy via nucleoporin POM121 in a NSC34 C9ALS/FTD model.

*Hsiang-En Wu¹, Shao-Ming Wang^2,4, Chun-Yu Lin^3,4, Fenf-Ju Weng^2,4, Hsuan-Cheng Wu^2,4, Leeodella Sands¹, Tsung-Ping Su¹ (1. Cellular Pathobiology Section, INRB, IRP, NIDA, NIH, 2. Graduate Institute of Biomedical Sciences, China Medical University, Taiwan, 3. School of Medicine, China Medical University, Taiwan, 4. 4Neuroscience and Brain Disease Center, China Medical University, Taiwan)

Keywords:amyotrophic lateral sclerosis, sigma-1 receptor, fluvoxamine