Preclinical - Others (2)

[P533] Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress

*Simon Couly¹, Yuko Yasui¹, Semnyonga Foncham¹, Ioannis Grammatikakis², Ashish Lal², Lei Shi³, Tsung-Ping Su¹ (1. Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute On Drug Abuse, NIH/DHHS, 333 Cassell Drive, Baltimore, MD, 21224, USA., 2. Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD, 20892, USA., 3. Computational Chemistry and Molecular Biophysics Section, Molecular Targets and Medications Discovery Branch, National Institute On Drug Abuse, NIH/DHHS, 333 Cassell Drive, Baltimore, MD, 21224, USA.)

Keywords:Endoplasmic reticulum, Mitochondria, MAM, Neurodegenerative disorders, Sigma-1 Receptor