[P27-10] P27-10: Pharmacokinetics and pharmacogenetics

[P27-10-8] Inhibitory effects of flavonoid-containing vegetables on CYP3A4 activity in recombinant CYP3A4 and LS180 cells

Masayuki Tsujimoto¹, Tomoe Uchida², Hiroyuki Kozakai³, Saori Yamamoto⁴, Chie Agawa⁵, Shinya Ueda⁶, Takayoshi Yamane⁷, Haruna Kitayama⁸, Aya Terao⁹, Tomoya Fukuda¹⁰, Tetsuya Minegaki¹¹, Kohshi Nishiguchi¹² (1.Kyoto Pharmaceutical University, 2.Kyoto Pharmaceutical University, 3.Kyoto Pharmaceutical University, 4.Kyoto Pharmaceutical University, 5.Kyoto Pharmaceutical University, 6.Kyoto Pharmaceutical University, 7.Kyoto Pharmaceutical University, 8.Kyoto Pharmaceutical University, 9.Kyoto Pharmaceutical University, 10.Kyoto Pharmaceutical University, 11.Kyoto Pharmaceutical University, 12.Kyoto Pharmaceutical University)

Keywords:vegetable juice, cytochrome P450 3A4, drug-food interaction, individual variation