10:20 〜 10:30
[O3-D-AM2-04] Surface temperature regulation by hemodynamic changes mediated by trigeminal afferents differs between intraoral and extraoral tissues
キーワード：Parasympathetic、Intra and extra oral tissues、TRP channels
Purpose: Surface temperature (Tm) in the skin or mucosa is critical in maintaining function and may be regulated by blood flow. blood flow velocity and magnitude.
Methods: Here, using urethane-anesthetized, cervically vago-sympathectomized rats, we investigated the role of trigeminal afferents in regulating surface Tm and hemodynamics in the intra and extra-oral tissues.
Results and Discussion: Lingual nerve (LN) stimulation resulted in significant elevations in surface Tm, as well as vasodilation in the lower lip and tongue. Pretreatment with the autonomic ganglion cholinergic blocker hexamethonium significantly inhibited both the surface Tm and vasodilation evoked by LN stimulation in the lower lip. However, in contrast to the lower lip, hexamethonium significantly reduced the Tm increase at the tongue surface, but the vasodilation caused by stimulation of LN remained apparently unchanged.
Conclusion: Our findings imply that parasympathetic reflex vasodilation regulates surface Tm in the orofacial region and that the interaction of parasympathetic and axon reflex vasodilation regulates surface Tm in some intraoral tissues.
Methods: Here, using urethane-anesthetized, cervically vago-sympathectomized rats, we investigated the role of trigeminal afferents in regulating surface Tm and hemodynamics in the intra and extra-oral tissues.
Results and Discussion: Lingual nerve (LN) stimulation resulted in significant elevations in surface Tm, as well as vasodilation in the lower lip and tongue. Pretreatment with the autonomic ganglion cholinergic blocker hexamethonium significantly inhibited both the surface Tm and vasodilation evoked by LN stimulation in the lower lip. However, in contrast to the lower lip, hexamethonium significantly reduced the Tm increase at the tongue surface, but the vasodilation caused by stimulation of LN remained apparently unchanged.
Conclusion: Our findings imply that parasympathetic reflex vasodilation regulates surface Tm in the orofacial region and that the interaction of parasympathetic and axon reflex vasodilation regulates surface Tm in some intraoral tissues.