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[P3-2-09] Antioxidant treatment facilitates alveolar bone formation after the periodontitis

〇Tae-Young Kim¹, Jung-Hyun Park², Yam Prasad Aryal¹, Elina Pokharel¹, Anna Kim¹, Chang-Hyeon An³, Wern-Joo Sohn⁴, Hitoshi Yamamoto⁵, Jae-Young Kim¹, Seo-Young An³ (1. Dept Biochem, Kyungpook Natl Univ Sch Dent , 2. Dept Mol Med, Ewha Womans Univ Coll Med, 3. Dept Oral Maxillofac Radiol, Kyungpook Natl Univ Sch Dent, 4. Dept K-Beauty Business, Daegu Hanny Univ Coll Cosme Pharm, 5. Dept Histol Dev Biol, Tokyo Dent Coll)

キーワード：Periodontitis、Bone regeneration、ROS

The periodontium develops from dental follicular tissue and is differentiated into periodontal ligament, cementum, and alveolar bone for bearing and supporting the tooth. Most of pathophysiological cases in periodontium are resulted into the loss of tooth. Among those, periodontitis is the main causes of tooth loss in dental field and required to be developed with proper medication. In this study, we evaluated the regenerative function of N-Acetyl cysteine (NAC), a well-known reactive oxygen species (ROS) scavenger, in bone healing processes of alveolar bone. The local delivery of NAC was employed after the tooth loss from the induction of periodontitis. The detailed histomorphological changes were examined using HE and MTC stainings after 1 week treatment. In addition, the precise localization patterns of various cell physiology and signaling molecules including 8-Hydroxy-2’-deoxyguanosine, CD31, IL1-β, KI67, MPO, Osteocalcin, and RUNX2 were examined. Micro-CT images confirmed the facilitated bone tissue formation in the NAC treated specimens compared with control. Overall, ROS scavenging would facilitate the bone formation through modulation of inflammation and signaling network in tooth loss root socket.