Poster session

[P3-3-21] Analysis of the signaling adaptor protein in oral candidiasis

〇Kenji Toyonaga^1,2, Jun-ichi Nagao^1,2, Sonoko Tasaki¹, Emi Kaji¹, Sari Kishikawa^1,2, Masanobu Nakagami¹, Aoba Iwanuma¹, Kanae Negoro¹, Yoshihiko Tanaka^1,2 (1. Div Infect Biol, Fukuoka Dent Coll, 2. Oral Med Res Ctr, Fukuoka Dent Coll)

Keywords:カンジダ症、感染防御、免疫受容体シグナル

Candida albicans (C. albicans) is a commensal fungus in humans that causes oral candidiasis and disseminated candidiasis in immunocompromised hosts. Although analysis of a murine model of systemic candidiasis has revealed important host defense mechanisms in disseminated candidiasis, the detailed control mechanisms for oral candidiasis are poorly understood. Therefore, we attempted to analyze the immune cells responsible for the effector functions against C. albicans and their regulatory mechanisms in a murine model of oral candidiasis (without immunosuppressive agents) by using gene-deficient mice for the signaling molecule downstream of immunoreceptor. In this presentation, we would like to discuss the role of immunoreceptor signaling during C. albicans oral infection.