[MO-32] Non-Ambulatory State among Hemodialysis Patients is Associates with Mortality and Lower Limb Events: Insights from PREDICT Study
【Objectives】It is well known that hemodialysis(HD) patients are at high risk for mortality and lower limb events, but impact of ambulatory state among HD patients is not established.
【Methods】 We analyzed data from the PREDICT study, a prospective multi-center observational cohort study, including 173 HD patients for diabetic nephropathy. Patients were enrolled between April 2012 to August 2013, and 29 patients were excluded due to lack of information about ambulatory state. 144 patients were classified into ambulatory group (n=106) or non-ambulatory group (n=38). The endpoints were major adverse limb events (MALE) including all-cause death, major amputation, lower limb revascularization.
【Results】After 2 years of follow-up, The Kaplan-Meier analysis (figure) showed incidence of MALE were significantly higher in non-ambulatory group than ambulatory group (log-rank p = 0.014). Multivariate analysis revealed that non-ambulatory state was significant predictors of MALE (p=0.024, hazard ratio=2.50, 95% confidence interval=1.13-5.53).
【Conclusions】Non-ambulatory state was associated with MALE. Appropriate care from early stage to avoid frailty may be important among HD patients.
【Methods】 We analyzed data from the PREDICT study, a prospective multi-center observational cohort study, including 173 HD patients for diabetic nephropathy. Patients were enrolled between April 2012 to August 2013, and 29 patients were excluded due to lack of information about ambulatory state. 144 patients were classified into ambulatory group (n=106) or non-ambulatory group (n=38). The endpoints were major adverse limb events (MALE) including all-cause death, major amputation, lower limb revascularization.
【Results】After 2 years of follow-up, The Kaplan-Meier analysis (figure) showed incidence of MALE were significantly higher in non-ambulatory group than ambulatory group (log-rank p = 0.014). Multivariate analysis revealed that non-ambulatory state was significant predictors of MALE (p=0.024, hazard ratio=2.50, 95% confidence interval=1.13-5.53).
【Conclusions】Non-ambulatory state was associated with MALE. Appropriate care from early stage to avoid frailty may be important among HD patients.