[2Xin5] インタラクティブ1

[2Xin5-02] Prediction of prognosis of active vitamin D preparation in patients with hypoparathyroidism using Medical Real World Data

〇Toshiki Iwai¹, Kyoko Katsumata¹, Yasuo Sugitani¹ (1.Chugai Pharmaceutical Co., Ltd. )

Keywords:Medical Data, Random Forest, hypoparathyroidism

Hypoparathyroidism is a disease characterized by hypocalcemia and hyperphosphatemia due to low levels of parathyroid hormone. The main symptoms of hypoparathyroidism are due to hypocalcemia, and include paresthesia, numbness, cramps, tetany, and convulsions. Oral active vitamin D and calcium preparations are the basis of standard therapy of chronic hypoparathyroidism to keep serum calcium levels. However, the main adverse effects of these therapies are hypercalcemia and hypercalciuria. In this study, we predicted the occurrence of benefits and risks of active vitamin D in patients with hypoparathyroidism using a medical real world data from clinical practice and evaluated the predictability. Although the prediction of benefit and risk could not be achieved sufficiently, certain results were obtained when limited to the prediction of benefit, and the factors contributing to the prediction model were partially interpretable.