The 76th JSAP Autumn Meeting, 2015

Presentation information

Oral presentation

4 JSAP-OSA Joint Symposia 2015 » 4.2 Bio- and Medical Photonics

[16p-2C-1~10] 4.2 Bio- and Medical Photonics

Wed. Sep 16, 2015 1:45 PM - 5:00 PM 2C (212-1)

Chair:Yuji Matsuura(Tohoku Univ.)

3:30 PM - 4:00 PM

[16p-2C-6] [JSAP-OSA Joint Symposia 2015 Invited Talk] Controlling cells function by light technology

〇Toshihiro Kushibiki1 (1.Nat Defense Med Coll)

Keywords:cells function,light

Technologies using lasers and light have numerous applications in the medical field, such as photo-diagnosis, endoscopy, laser dissection, and photodynamic therapy. In the field of basic biological research, lasers and light are essential tools not only in detection devices but also with microscopy and imaging techniques.
The focus of my research is the response of living organisms and/or their tissues after laser radiation or light exposure. Since 1970, Mester et al. have reported that low-level laser therapy induces wound healing, cell proliferation, ATP synthesis, collagen synthesis, anti-inflammation, pain relief, osteogenesis, and many other biological effects. The detailed mechanisms of these effects are still not clear, although there are a few molecular biology-based studies in the literature.
For controlling cell function and homeostasis, genetic technology, such as transgene and knock-in or knock–out methods, and medications are widely used. However, non-invasive technology, such as stem cell therapy and cell-based diagnosis, could prove to be useful in the fields of medicine and biology. These technologies could obviate the need for conventional methods, which are often invasive and can have adverse side effects.
In this lecture, I will present my results showing that using lasers alone, cell function can be controlled without any need for genetic technologies. My research goal is to develop technologies and methods that actively utilize light energy for diagnostic and treatment purposes. Moreover, I ultimately hope to develop applied optical technologies that are non-invasive to living organisms and can replace genetic engineering and medications.