[14p-P19-1~20] 12.7 Biomedical Engineering and Biochips

[14p-P19-14] Beat of cardiac cell aggregates induced by mechanical stimulus

〇Takahiro Uehara¹, Shin Arai¹, Ayaha Tsuyuki¹, Kentaro Ishida¹, Toshiyuki Mitsui¹ (1.Aogaku Univ)

Keywords:heart, stimulus, beat

In order to keep the cyclic contract/relax motions in the heart, mechano-electric coupling plays an important role likely controlled by stretch-activated channels. To inspect the coupling, the response to mechanical stimuli on cardiac cell aggregates in a dish has been experimentally observed. The stimulus can generate a contract/relax motion locally and generate action potential propagation.