[14p-P19-1~20] 12.7 Biomedical Engineering and Biochips

△ [14p-P19-6] Characterization of Molecularly Imprinted Polymer-gate Field Effect Transistor for Selective Molecular Recognition

〇(M1)Shoichi Nishitani¹, Taira Kajisa², Toshiya Sakata¹ (1.Univ. of Tokyo, 2.PROVIGATE Inc.)

Keywords:field effect transistor, molecularly imprinted polymer, characterization

Our group has been developing a molecularly imprinted polymer-coated gate field effect transistor for specific molecular recognition in aqueous media. In this study, we applied Batch Rebinding method to the results achieved from FET real-time measurement, to characterize MIP-gate FETs for variety of targets, by fitting several isotherm equations. As a consequence, we found out that the signal from FET can be well explained by isotherm equations such as Langmuir and Freundlich, and thus, achieved a method to characterize MIP-gate FET. This enables us to compare the selectivity enhanced by MIP, as well as strategically design MIPs for variety of target molecules.