[15a-P1-1~4] 1.1 Interdisciplinary and General Physics

[15a-P1-4] numerical simulations and mathematical analysis of synaptic plasticity based on the rates of presynaptic firing

〇Katsuhiko Hata^1,2,3, Osamu Araki⁴, Osamu Yokoi^1,3, Toshiaki Kaminaka^1,3 (1.Res.Cent. for Math.Med., 2.Sakurai Hosp., 3.DPEMS, Kokushikan Univ., 4.Dept. of Ap.Phys. TUS)

Keywords:synaptic plasticity, neurons, brain

In the brain, many neurons transmit signals to each other via synaptic connections. The change in this connection strength is called “synaptic plasticity”, which is essentially involved in memory and learning. Synaptic plasticity is generally classified into long-term potentiation (LTP) and long-term depression (LTD). LTP/LTD is a long-lasting strengthening/ weakening in synaptic signal transmission. In the hippocampus of the brain, stimulation of synaptic input fibers with a frequency of 10-100 Hz triggers LTP. LTD, on the other hand, is induced by low frequency stimulation of 1-5 Hz. In this study, we investigate numerically and analytically the synaptic plasticity dependent on the frequency of stimulation.