[16p-F205-1~18] 12.7 Biomedical Engineering and Biochips

[16p-F205-17] Molecular Imprinting Polymer Forming on Quartz Crystal Microbalance with Plasma Initiated Polymerization for Heparin Sensor The Second Report

〇(M1)Atsushi Hikichi¹, Hitoshi Muguruma¹, Tomohiko Arita¹, Yasuo Yoshimi¹ (1.Shibaura Inst. Tech.)

Keywords:Molecular Imprinting Polymer, Heparin, Plasma Initiated Polymerization

Heparin is the most important anticoagulant drug used during surgeries and extracorporeal therapies. Although the blood levels of heparin should be monitored continuously during the procedure to ensure the safety of the patient, there is currently no technique for measuring heparin in real time. This study describes the use of a molecularly imprinted polymer (MIP) as a recognition element in the development of a heparin sensor for real-time monitoring. MIP is formed on quartz crystal microbalance (QCM) with plasma initiated polymerization. Heparin is bound on QCM and heparin analog chondroitin sulfate C is not done, indicating that MIP for template heparin is successfully completed.