[16p-F205-1~18] 12.7 Biomedical Engineering and Biochips

[16p-F205-18] High sensitive inspection chip for influenza virus based on the local surface plasmon resonance

〇Akira Monkawa¹, Yuki Takimoto¹, Tomoko Gessei¹ (1.TIRI)

Keywords:localized surface plasmon resonances

Influenza pandemics spread around the world, resulting in the deaths of millions in pandemic years. Antivirals are a powerful tool in the fight against the virus, but they must be administered within 48 h of infection for optimal efficacy. Therefore, the rapid detection of the viruses is important technology. Influenza virus can be detected by the quantification of hemagglutinin (H) using immunogenic methods, but this is considered inefficient, mainly due to its low analytical accuracy and throughput capacity. We have developed a sensitive microscale binding assay to study the interaction between hemagglutinin and sialic acid using localized surface plasmon resonances (LSPR).