[20p-PA4-1~23] 12.7 Biomedical Engineering and Biochips

[20p-PA4-17] Detection of gold nanoparticle aggregation by addition of biomolecules inside an optical fiber spectroscopic cell

〇Masahiko Shiraishi¹, Kazuhiro Watanabe¹, Shoichi Kubodera¹ (1.Soka Univ.)

Keywords:Biological sensing, Optical fiber sensor, Femtosecond processing

A microhole structure penetrating a glass optical fiber was fabricated by femtosecond laser drilling. The microhole works as an optical fiber spectroscopic cell which has sensing volume of picoliters, since the spectroscopic cell is capable of interacting liquid samples introduced into the cell with propagating light in the optical fiber. A solution of gold nanoparticles was injected into the spectroscopic cell, and the optical absorption spectrum peculiar to the gold nanoparticles was observed. Furthermore, an aggregation of gold nanoparticles caused by addition of biomolecules was monitored by the change in the absorption spectrum.