[21a-144-1~13] 8.4 Plasma life sciences

[21a-144-13] Metabolomics of glioblastoma cells incubated with plasma-activated lactate (2)

〇Kenji Ishikawa¹, Yugo Hosoi¹, Hiroshi Hashizume¹, Hiromasa Tanaka¹, Shinya Toyokuni¹, Fumitaka Kikkawa¹, Masaaki Mizuno¹, Masaru Hori¹ (1.Nagoya Univ.)

Keywords:Plasma medicine, Plasma activated lactate, Metabolism

In cancer therapy, for example, modifications of liquids in contact with cells or tissues play important role in the resulting effects. Together with effects on cell membranes resulting from plasma-induced changes in electric fields, responses to the reactive species also occur. We have studied radical kinetics and electrical effects to fully elucidate these phenomena. Controlling these reactions is difficult due to the nonequilibrium states that are thermodynamically unfavorable. To overcome this challenge, the dynamic behavior of plasmas must be characterized in situ at all hierarchical levels (i.e., liquid, cell, tissue, organ, body).