[19p-A302-1~23] 3.4 Biomedical optics

[19p-A302-19] Development of High Sensitivity Photothermal Microscopic Imaging

〇Takayoshi Kobayashi^1,2, Kazuaki Nakata^1,2, Eiji Tokunaga², Hiromichi Tsurui³, Jun Miyazaki⁴, Koshi Kawasumi⁵ (1.Univ. Electro-Comm. Brain, 2.Tokyo Univ. Sci. Phys., 3.Juntendo Univ., 4.Wakayama Univ., 5.Olympus)

Keywords:Photothermal Microscopic Imaging, Non-linear, high-resolution

In our previous studies, we developed highly sensitive, high-resolution, and fast-imaging photothermal microscopy by employing an inverse-ring aperture filter, a Galvano mirror, and a space-division balance detection scheme. In the present study we report high-resolution photothermal, which we call PT, microscopy, using non-linear signal detection. By detecting the PT signal from the microscope, we could obtain resolution improvement from the values of diffraction limit of pump and probe by 61 and 42%, respectively.