[19p-PB1-1~34] 12.7 Biomedical Engineering and Biochips

[19p-PB1-10] In vivo neuronal recordings in model mouse with diabetes via 5-µm-diameter needle-electrode

〇Rioki Sanda¹, Hirohito Sawahata², Shota Yamagiwa¹, Koji Yamashita¹, Rika Numano¹, Kowa Koida¹, Takeshi Kawano¹ (1.Toyohashi Tech., 2.INCT)

Keywords:neuroprobe, model mouse with diabetes, in vivo recording

The number of people with diabetes, which is one of lifestyle related diseases, has been rising more rapidly. Diabetes complicates peripheral vascular disease, ultimately causing risk factors for lower-extremity amputation. Brain-machine interface technology, which restores motor function by acquiring neuronal signals from the brain, is a way to improve the quality of life of such patients with diabetes. However, conventional electrode devices cause damage to the brain tissue, due to the large geometry of electrode. In this research, we explored the recording capability of world's finest <5-μm-diameter microneedle-electrode device, using abnormal vascular disordered brain tissues of mice with diabetes.