[20p-B32-1~7] Symbiosis of solid- and bio-surface: Toward a seamless communication between cyberspace and real life world

[20p-B32-4] Monitoring Molecular Interaction in single live cells using light microscopy

Tomoko Inose¹, Beatrice Fortuni², Monica Ricci², Kenji Hirai¹, Susana Rocha², 〇Hiroshi Uji-i^1,2 (1.Hokkaido Univ. RIES, 2.KU Leuven)

Keywords:single cell, enhanced Raman

In this contribution, I will introduce a noble spectroscopic method to monitor inter-molecular interaction inside a living cell. We use noble metal nanowire as plasmonic waveguide to excite surface enhanced Raman scattering (SERS) through propagating plasmons. In such a way, Raman signal containing inter-molecular interaction inside live cells can be obtained without disturbing cell health. As an example, time evaluation of interaction between anti-cancer drug molecules and DNA will be discussed in this talk.