[11a-W810-1~10] 31.1 Focused Session "AI Electornics"

△ [11a-W810-4] Three-Dimensional Structural Analysis of Human Brain Network with Synchrotron Radiation Nanotomography

〇Nana Sato¹, Sakura Katana¹, Susumu Takekoshi², Chie Inomoto², Naoya Nakamura², Makoto Arai³, Kenichi Oshima³, Masanari Itokawa³, Youta Torii⁴, Itaru Kushima⁴, Shuji Iritani⁴, Norio Ozaki⁴, Akihisa Takeuchi⁵, Kentaro Uesugi⁵, Yasuko Terada⁵, Yoshio Suzuki⁶, Vincent De Andrade⁷, Francesco De Carlo⁷, Rino Saiga¹, Ryuta Mizutani¹ (1.Tokai Univ., 2.Tokai Univ. Sch. Med., 3.Tokyo Metropolitan Inst.Med.Sci., 4.Nagoya Univ., 5.JASRI/SPring-8., 6.Univ.Tokyo, 7.Argonne Nat'l Lab.)

Keywords:nano-CT, X-ray, 3D

Brain is consisted of a huge number of neurons which shape 3D networks. This study reports a 3D analysis of human brain neurons of schizophrenia and control cases using synchrotron radiation nanotomography. Cerebral tissues were taken from the anterior cingulate cortex. It has been reported that this brain area is responsible for higher brain functions including decision-making, and has relationships to psychiatric diseases. Synchrotron radiation nanotomography was performed at the 32-ID beamline of Advanced Photon Source of Argonne National Laboratory and at the BL37XU and the BL47XU beamlines of SPring-8. Neuronal networks in the 3D images were traced to build Cartesian coordinate models of neurons. The obtained models indicated that neuronal structures are different between individuals, and those differences become extraordinary in schizophrenia. We suggest that the structural variety of neurons represent the mental individuality of humans.