[11p-M113-1~20] 6.2 Carbon-based thin films

[11p-M113-9] Antenna-integrated cell culture dishes and their use for intracellular nanodiamond quantum thermometry of stem cells

〇Masazumi Fujiwara¹, Hiroshi Yukawa², Kaori Kobayashi², Yumi Umehara¹, Yuka Kumon², Kazu Miyaji², Takayuki Iwasaki³, Mutsuko Hatano³, Hideki Hashimoto⁴, Yoshinobu Baba² (1.Osaka City Univ., 2.Nagoya Univ., 3.Tokyo Inst. Tech., 4.Kwansei Gakuin Univ.)

Keywords:Nanodiamond, Electron spin

We demonstrated stable and nontoxic thermometry of adipose-tissue derived stem cells (ASCs) by using quantum sensors based on the optically detectable electron spin resonance of fluorescent nanodiamonds. ASCs were labeled with nanodiamonds while retaining their abilities of self-proliferation and differentiation to osteocytes and adipocytes. The labeled ASCs were measured by the quantum thermometry to detect the intracellular temperature changes.