[11p-M121-1~10] Interplay and integration of experiments and calculations in nanobiotechnology: lipid membrane and membrane proteins

[11p-M121-4] Direct observation of membrane fusion

Masato Yamada¹, 〇Rikiya Watanabe² (1.Univ. Tokyo, 2.CPR, RIKEN)

Keywords:membrane protein, biomembrane, membrane fusion

Membrane vesicles mediate various physiological functions upon fusion with biological membranes. Despite the physiological importance, biophysical features of membrane fusion remain elusive due to the technical difficulties to quantitatively measure fusion events in high throughput manner. To address this issue, we here attempted to elucidate various biophysical features of membrane fusion by developing a novel microsystem, enabling single particle analysis of membrane fusion in quantitative manner.