[9p-M136-1~7] 12.3 Functional Materials and Novel Devices

[9p-M136-3] Tissue-adhesive light-emitting device for implantable photodynamic cancer therapy

〇(PC)Kento Yamagishi¹, Izumi Kirino², Isao Takahashi³, Hizuru Amano⁴, Shinji Takeoka³, Yuji Morimoto⁵, Toshinori Fujie^6,7,8 (1.Res. Org. Nano & Life Innov., Waseda Univ., 2.Grad. Sch. Med., Kyoto Univ., 3.Grad. Sch. Adv. Sci. Eng., Waseda Univ., 4.Grad. Sch. Med., Univ. Tokyo, 5.Dept. Physiol., NDMC, 6.WIAS, Waseda Univ., 7.JST PRESTO, 8.Sch. Life Sci. Technol., Tokyo Tech.)

Keywords:Photodynamic therapy, Implantable device, Polymer nanosheet

We developed a tissue-adhesive sheet-like optical device that can be secured onto the biological tissue surfaces for implantable photodynamic cancer therapy. Wirelessly powered LED chips were sealed with polydopamine-modified silicone rubber nanofims (~600 nm thick). The device was subcutaneously implanted in the intradermal tumor model mice. After administration of a photosensitizer into the mice, the implanted optical device locally irradiated the target tumors for 10 days, of which light intensity was 1,000-fold lower than conventional photodynamic therapy approaches, and demonstrated remarkable antitumor effect including complete disappearance of tumors.