[14a-A304-1~9] 8.4 Plasma life sciences

△ [14a-A304-5] Study on Mechanism of Drug Simulated Molecule Introduction by Direct In-liquid Plasma Treatment

〇Ryosuke Honda¹, Shota Sasaki¹, Keisuke Takashima¹, Makoto Kanzaki², Takehiko Sato³, Toshiro Kaneko¹ (1.Grad.Sch.of Eng.,Tohoku Univ., 2.Grad. Sch. of Med. Eng.,Tohoku Univ., 3.Inst. of Fluid Sci.,Tohoku Univ.)

Keywords:In-liquid plasma

We conducted experiments to clarify the mechanism of drug simulated molecule introduction induced by in-liquid plasma toward a minimally invasive treatment in human body. Direct irradiation of in-liquid plasma significantly enhanced YOYO-1 introduction into cultured cells compared to indirect irradiation and addition of superoxide dismutase did not inhibit the YOYO-1 introduction effect by the direct irradiation. Therefore, it was considered that the key factor of the plasma-induced YOYO-1 introduction might be not short-lived reactive species such as O₂^•− but electrical and mechanical stimuli caused by the in-liquid plasma.