[11a-N201-1~10] Optical/magnetic control of biological functions for the elucidation of biological systems

[11a-N201-4] Multicolor 3D cellular stimulation method in deep tissue using rare-earth doped probes

〇Taichi Furukawa^1,2, Koji Matsui¹, Yoshiyuki Kuroda¹, Shoji Maruo¹ (1.Yokohama National Univ., 2.JST-PRESTO)

Keywords:Rare-earth doped phosphors, Optogenetics, Upconversion

In recent years, up-conversion (UC) phosphors, which can excite near-infrared light to emit visible light, have been used in optogenetics to control cellular functions in the deep brain. However, in conventional deep photo-stimulation methods using UC phosphors, it is difficult to stimulate opsins at a cellular scale and control emission colors in the same area. In this study, we developed two-wavelength excited UC phosphors to overcome these difficulties and considered their capability to optogenetics in deep tissues.