[11a-N201-1~10] Optical/magnetic control of biological functions for the elucidation of biological systems

[11a-N201-5] Magnetic Nanotools for Observing and Modulating Brain Functions by Application of Magnetic Field

〇Satoshi Okada^1,2, Vivian Hsieh³, Satoko Takayasu⁴, Akira Sumiyoshi⁵, Alan Jasanoff³, Ichio Aoki⁵, Hiroyuki Nakamura¹ (1.Tokyo Tech., 2.PRESTO, JST, 3.MIT, 4.AIST, 5.QST)

Keywords:MRI, magnetic nanoparticles, molecular probes

Optical techniques using ultraviolet-visible light are useful for molecularly specific analysis but the applicable field is localized. We developed magnetic nanotools expressing functions in a signaling pathway dependent manner in order to observe and modulate wide and deep regions of brain activity at the molecular level without genetic engineering. Here we will mainly introduce an observation technique based on neurotransmitter-responsive magnetic nanoprobes and their application to MR imaging.