17:30 〜 17:45
[16p-Z24-16] ナノシートにより強化した生体適合性ハイドロゲルの作製
キーワード：ハイドロゲル、ゾルゲル転移、ナノコンポジットポリマー
Hydrogels including hydrophilic homo-polymer or copolymer networks are commonly used as biomaterials due to their biocompatibility, effective mass transfer, flexibility. Pluronic nonionic triblock copolymers are reverse thermo responsive hydrogels containing hydrophilic polyethylene oxide (PEO) groups connected to both ends of hydrophobic polypropylene oxide (PPO) groups. Among the different type of pluronics, F-127 shows a simple phase diagram and forms a gel at room temperature while being a solution at low temperature. One of the limitations of the practical use of hydrogels is their poor mechanical properties. Cross-linking between polymers and the reinforcements with the use of nanoparticles or nanosheets represent some possibilities to overcome those issues.
In this research study, a hybrid hydrogel was prepared by mixing nanosheets with F-127 functionalized by dimethacrylate (F-127-DMA) forming a gel at room temperature. Hexaniobate exfoliated by tetrabutylammonium hydroxide (TBAOH), montmorillonite with pentaethylene glycol monodecyl ether (C10E5) and pure montmorillonite were used as reinforcers in F-127-DMA. By following the rheological properties of nanocomposite-based hydrogels, the effect of the inclusion of several nanosheets (hydrophilic or hydrophobic) on the gel formation (sol-gel transition) was investigated. Hybrid hydrogels using hydrophobic nanosheets showed a decrease in gelation temperature and an increase in storage modulus (G’). On the other hand, the opposite trend was observed with hydrophilic nanosheets, underlining the probable enhancement of the global properties of the F-127 gel by the inclusion of hydrophobic nanosheets.
In this research study, a hybrid hydrogel was prepared by mixing nanosheets with F-127 functionalized by dimethacrylate (F-127-DMA) forming a gel at room temperature. Hexaniobate exfoliated by tetrabutylammonium hydroxide (TBAOH), montmorillonite with pentaethylene glycol monodecyl ether (C10E5) and pure montmorillonite were used as reinforcers in F-127-DMA. By following the rheological properties of nanocomposite-based hydrogels, the effect of the inclusion of several nanosheets (hydrophilic or hydrophobic) on the gel formation (sol-gel transition) was investigated. Hybrid hydrogels using hydrophobic nanosheets showed a decrease in gelation temperature and an increase in storage modulus (G’). On the other hand, the opposite trend was observed with hydrophilic nanosheets, underlining the probable enhancement of the global properties of the F-127 gel by the inclusion of hydrophobic nanosheets.